We focus on structurally inspiring target molecules with a propensity to address regulatory interactions of proteins with cellular macromolecules and interesting or unknown modes-of-action. We currently pursue research into syntheses of natural products, peptide alkaloids, synthetic peptide collections and chemical inducers of dimerization.
A far reaching goal is blending peptide architecture with the diversity of natural product structures. To achieve this, we investigate syntheses, non-natural modifications and properties of peptides, often guided by biomimetic considerations.
In order to uncover molecular structures with novel or improved activity profiles, biochemical testing is integrated in our research program. For mode of action studies, we use fluorescently labeled modulator compounds for assays and cell microscopy and covalent attachment reactions to biomolecules. Moreover, new formats of engineered reactivity of modulator ligands with proteins are developed and explored.
For more details please refer to our publications.
