Publications

2021

V. Nasufovic, F. Küllmer, J. Bößneck, H.-M. Dahse, H. Görls, P. Bellstedt, P. Stallforth, H.-D. Arndt, "Total synthesis and bioactivity mapping of geodiamolide H"

F. Küllmer, L. Gregor, H.-D. Arndt, "Tailoring of Asymmetric Azobenzenes for Photoswitching"

E. Molloy, M. Dell, V. Hänsch, K. L. Dunbar, R. Rietschel, A. Oberheide, L. Seyfarth, J. Kumpfmüller, T. Horch, H.-D. Arndt, C. Hertweck, "Enzyme-Primed Native Chemical Ligation Produces Autoinducing Cyclopeptides in Chlostridia", in revision.

S. Pospich, F. Küllmer, V. Nasufovic, J. Funk, A. Belvy, P. Bieling, H.-D. Arndt, S. Raunser, "Cryo-EM resolved molecular recognition of an optojasp photoswitch bound to actin filaments in both switch statesExterner Link", Angew. Chem. 2021, advance article.

V. Nasufovic, P. Then, F. Dröge, M. Duong, B. Dietzek, R. Heintzmann, H.-D. Arndt, "Si-Rhodamine isothiocyanate as a fluorescent labeling toolExterner Link", Org. Biomol. Chem. 2021, 19, 574-578.

2020

A. Oberheide, H.-D. Arndt, "Effective C5-arylation of peptide-integrated oxazoles: Almazole DExterner Link", Adv. Synth. Catal. 2020, early view (DOI 10.1002/adsc.202001262)

R. R. A. Freund, M. van den Borg, D. Gassmaier, R. Schlosser, T. Jacob, H.-D. Arndt, "Cornforth-Evans transition states in stereocontrolled allylborations of epoxy aldehydesExterner Link", Chem. Eur J. 2020, 26, 8639-8650.

M. Borowiak, F. Küllmer, F. Gegenfurtner, S. Peil, V. Nasufovic, S. Zahler, O. Thorn-Seshold, D. Trauner, H.-D. Arndt, "Optical manipulation of F-actin with photoswitchable small moleculesExterner Link", J. Am. Chem. Soc. 2020, 142, 9240-9249 (press releaseExterner Link of FSU Jena; featured on local radio SRBExterner Link in GermanExterner Link)

R. A. Freund, P. Gobrecht, D. Fischer, H.-D. Arndt, "Advances in parthenolide chemistry and biologyExterner Link", Nat. Prod. Rep. 2020, 37, 541-565.

M. Sauer, V. Nasufovic, H.-D. Arndt, I. Vilotijevic, "Robust Synthesis of NIR-emissive P-Rhodamine FluorophoresExterner Link", Org. Biomol. Chem. 2020, 18, 1567-1571.

 

2019

R. R. A. Freund, P. Gobrecht, P. Moser, D. Fischer, H.-D. Arndt, "Synthesis and biological profiling of parthenolide ether analogsExterner Link", Org. Biomol. Chem. 2019, 17, 9703-9707.

A. Müller, S. Müller, V. Nasufovic, H.-D. Arndt, T. Pompe, "Actin stress fiber dynamics in laterally confined cellsExterner Link", Integr. Biol. 2019, 11, 175-185.

R. R. A. Freund, P. Gobrecht, Z. Rao, J. Gerstmeier, R. Schlosser, H. Görls, O. Werz, D. Fischer, H.-D. Arndt, "Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activityExterner Link", Chem. Sci. 2019, 10, 7358-7364.

A. Oberheide, S. Schwenk, C. Ronco, L.-M. Semmrau, H. Görls, H.-D. Arndt, "Synthesis, Structures, and Cytotoxicity of Urukthapelstatin A Polyazole Cyclopeptide AnalogsExterner Link", Eur J. Org. Chem. 2019, 4320-4326 (cover featureExterner Link: Eur J. Org. Chem. 2019, 4272).

S. Krieck, D. Kalden, A. Oberheide, L. Seyfarth, H.-D. Arndt, H. Görls, M. Westerhausen, "Synthesis and Catalytic Activity of Tridentate Externer LinkN-(2-Pyridylethyl)-Substituted Bulky Amidinates of Calcium and StrontiumExterner Link", Dalton Trans. 2019, 48, 2479-2490.

A. Oberheide, S. Pflanze, P. Stallforth, H.-D. Arndt, "Solid Phase Based Total Synthesis and Stereochemical Assignment of the Cryptic Natural Product AurantizolicinExterner Link", Org. Lett. 2019, 21, 729-732.

2018

F. Merino, S. Pospich, J. Funk, F. Küllmer, H.-D. Arndt, P. Bieling, S. Raunser, "Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo EMExterner Link", Nat. Struct. Mol Biol. 2018, 25, 528-537.

C. Rößler, H.-D. Arndt, "A master switch in thiopeptide biosynthesisExterner Link", Cell Chem. Biol. 2018, 25, 121-123.

 

2017

S. Zergiebel, H.-D. Arndt, A. Seeling, "Optimized Synthesis of new LE404-derived azecine-prodrugsExterner Link", Tetrahedron Lett. 2017, 58, 3640-3642.

S. Zergiebel, C. Fleck, H.-D. Arndt, C. Enzensperger, A. Seeling, "Synthesis and Characterization of new Azecine-Derivatives as Potential NeurolepticsExterner Link", Drug. Res. 2017, 67, 466-475.

K. B. Jadhav, C. Stein, O. Makarewicz, G. Pradel, R. J. Lichtenecker, H. Sack, S. H. Heinemann, H.-D. Arndt, "Bioactivity of topologically confined gramicidin A dimersExterner Link", Bioorg. Med. Chem. 2017, 25, 261-268.

2016

Y. Yonemura, X. Li, K. Müller, A. Krämer, P. Atigbire, T. Mentrup, T. Feuerhake, T. Kroll, O. Shomron, R. Nohl, H.-D. Arndt, C. Hoischen, P. Hemmerich, K. Hirschberg, C. Kaether, "Inhibition of cargo export at ER-exit sites and the trans-Golgi network by the secretion inhibitor FLI-06Externer Link", J. Cell. Sci. 2016, 129, 3868-3877.

R. R. A. Freund, H.-D. Arndt, "Synthesis of (±)-4,5-dia-parthenolide, an unnatural parthenolide stereoisomerExterner Link", J. Org. Chem. 2016, 81, 11009-11016.

L. Gelis, N. Jovancevic, S. Veitinger, B. Mandal, H.-D. Arndt, E. M. Neuhaus, H. Hatt, "Functional characterization of the odorant receptor 51E2 in human melanocytesExterner Link", J. Biol. Chem. 2016, 291, 17772-17786

K. P. Wojtas, J.-Y. Lu, D. Krahn, H.-D. Arndt, "Regioselective functionalization of 3-hydroxypyridine carboxylates by neighboring group assistanceExterner Link", Chem. Asian J. 2016, 11, 2859-2862.

S. Schwenk, C. Ronco, A. Oberheide, H.-D. Arndt, "Biomimetic synthesis of urukthapelstatin A by Aza-Wittig ring contractionExterner Link", Eur. J. Org. Chem. 2016, 4795-4799.

K. P. Wojtas, M. Riedrich, J.-Y. Lu, P. Winter, T. Winkler, S. Walter, H.-D. Arndt, "Total synthesis of nosiheptideExterner Link", Angew. Chem. 2016, 128, 9924-9928; Angew. Chem. Int. Ed. 2016, 55, 9772-9776.

 

2015

H. B. Bode, A. O. Brachmann, K. B. Jadhav, L. Seyfarth, C. Dauth, S. W. Fuchs, M. Kaiser, N. R. Waterfield, H. Sack, S. H. Heinemann, H.-D. Arndt, "Structure elucidation and activity of the giant-NRPS derived D-/L-pentadecapeptide kolossin AExterner Link", Angew. Chem. 2015, 127, 10493-10496; Angew. Chem. Int. Ed. 2015, 54, 10352-10355; Highlighted inExterner Link Nachr. Chem. 2015, 63, 974.

K. B. Jadhav, R. J. Lichtenecker, A. Bullach, B. Mandal, H.-D. Arndt, "Dynamic combinatorial enrichment of polyconformational D-/L-peptide dimersExterner Link", Chem. Eur. J. 2015, 21, 5898-5908.

H.-D. Arndt, S. Rizzo, C. Nöcker, V. N. Wakchaure, L.-G. Milroy, V. Bieker, A. Calderon, T. T. N. Tran, S. Brand, L. Dehmelt, H. Waldmann, "Covalent divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides - Total synthesis of seragamide AExterner Link", Chem. Eur. J. 2015, 21, 5311-5316.

 

2014

A. Wolf, S. Schoof, S. Baumann, H.-D. Arndt, K. N. Kirschner, "Structure-activity relationships of thiostrepton derivatives: Implications for rational drug designExterner Link", J. Comput.-Aided Mol. Des. 2014, 28, 1205-1215.

G. Lukinavičius, L. Reymond, E. d'Este, A. Masharina, F. Göttfert, H. Ta, A. Güther, M. Fournier, S. Rizzo, H. Waldmann, C. Blaukopf, C. Sommer, D. W. Gerlich, H.-D. Arndt, S. W. Hell, K. Johnsson, "Fluorogenic probes for live-cell imaging of the cytoskeletonExterner Link", Nat. Methods 2014, 11, 731-733.

2013

R. J. Lichtenecker, B. Ellinger, H.-M. Han, K. B. Jadhav, S. Baumann, O. Makarewicz, M. Grabenbauer, H.-D. Arndt, "Iterative antimicrobial candidate selection from informed D-/L-peptide librariesExterner Link", ChemBioChem 2013, 14, 2492-2499.

A. Krämer, T. Mentrup, B. Kleizen, E. Rivera-Milla, D. Reichenbach, C. Enzensperger, R. Nohl, E. Täuscher, H. Görls, A. Ploubidou, C. Englert, O. Werz, H.-D. Arndt, C. Käther, "Small moleculesExterner Link intercept Notch signalingExterner Link and the early secretory pathwayExterner Link", Nat. Chem. Biol. 2013, 9, 731-738.

J.-Y. Lu, M. Riedrich, K. P. Wojtas, H.-D. Arndt, "Assembly of the nosiheptide A-ring: A fruitful lessonExterner Link", Synthesis 2013, 1300-1311.

P. Loos, C. Ronco, M. Riedrich, H.-D. Arndt, "Unified Azoline and Azole Syntheses by Optimized Aza-Wittig ChemistryExterner Link", Eur. J. Org. Chem. 2013, 3290-3315.

 

2012

A. Wolf, S. Baumann, H.-D. Arndt, K. N. Kirschner, "Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulationExterner Link", Bioorg. Med. Chem. 2012, 20, 7194-7205.

L.-G. Milroy, S. Rizzo, A. Calderon, B. Ellinger, S. Erdmann, J. Mondry, P. Verveer, P. Bastiaens, H. Waldmann, L. Dehmelt, H.-D. Arndt, "Selective chemical imaging of static actin in live cellsExterner Link", J. Am. Chem. Soc. 2012, 134, 8480-8486.

M. N. Aminake, H.-D. Arndt, G. Pradel, "The proteasome of malaria parasites: a multi-stage drug target for chemotherapeutic intervention?Externer Link", Int. J. Parasitol. Drugs Drug Res. 2012, 2, 1-10.

 

2011

L. Iovkova, D. Könning, B. Wängler, R. Schirrmacher, S. Schoof, H.-D. Arndt, K. Jurkschat, "SiFA-Modified Phenylalanine: A Key Compound for the Efficient Synthesis of Externer Link¹⁸F-Labelled PeptidesExterner Link", Eur. J. Inorg. Chem. 2011, 14, 2238-2246.

Y.-P. He, H. Tan, L. Arve, S. Baumann, H. Waldmann, H.-D. Arndt, "Biphenomycin B and Derivatives: Total Synthesis and Translation InhibitionExterner Link", Chem. Asian J. 2011, 6, 1546-1556. 

S. Basu, B. Ellinger, S. Rizzo, C. Deraeve, M. Schürmann, H. Preut, H.-D. Arndt, H. Waldmann, "Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small molecule activator of the Wnt-pathwayExterner Link", Proc. Natl. Acad. Sci. USA 2011, 108, 6805-6810.

M. N. Aminake, S. Schoof, L. Sologub, M. Leubner, M. Kirschner, H.-D. Arndt, G. Pradel, "Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting the parasite proteasome and apicoplastExterner Link", Antimicrob. Agents Chemother. 2011, 55, 1338-1348. 

H. R. A. Jonker, S. Baumann, A. Wolf, F. Hiller, S. Schoof, K. W. Schulte, K. N. Kirschner, H. Schwalbe, H.-D. Arndt, "NMR structures of thiostrepton derivatives reveal shape selective target recognitionExterner Link", Angew. Chem. 2011, 123, 3366-3370; Angew. Chem. Int. Ed. 2011, 50, 3308-3312.

 

2010

S. Baumann, S. Schoof, M. Bolten, C. Haering, M. Takagi, K. Shin-ya, H.-D. Arndt, "Molecular determinants of microbial resistance to thiopeptide antibioticsExterner Link", J. Am. Chem. Soc. 2010, 132, 6973-6981. 

C. P. R. Hackenberger, H.-D. Arndt, D. Schwarzer, "Semisynthese: Ein zentrales Werkzeug für die Chemische BiologieExterner Link", Chem. Unserer Zeit 2010, 44, 198-206.

H.-D. Arndt, C. P. R. Hackenberger, D. Schwarzer, "Semisynthese: Chemie mit den Molekülen der NaturExterner Link", Chem. Unserer Zeit 2010, 44, 130-137. 

S. Schoof, G. Pradel, M. N. Aminake, B. Ellinger, S. Baumann, M. Potowski, Y. Najajreh, M. Kirschner, H.-D. Arndt, "Anti-plasmodial thiostrepton derivatives are proteasome inhibitors with a dual mode of actionExterner Link", Angew. Chem. 2010, 122, 3389-3393; Angew. Chem. Int. Ed. 2010, 49, 3317-3321. 

R. Tannert, L.-G. Milroy, T.-S. Hu, B. Ellinger, S. Menninger, H.-D. Arndt, H. Waldmann, "Synthesis and structure-activity correlation of natural-product inspired cytotoxic cyclodepsi­peptides stabilizing actinExterner Link", J. Am. Chem. Soc. 2010, 132, 3063-3077.

 

2009

J.-Y. Lu, M. Riedrich, M. Mikyna, H.-D. Arndt, "Aza-Wittig-enabled synthesis of the nosiheptide A-RingExterner Link", Angew. Chem. 2009, 121, 8281-8284; Angew. Chem. Int. Ed. 2009, 48, 8137-8140.

S. Schoof, H.-D. Arndt, "D-Cysteine occurrence in thiostrepton may not necessitate an epimeraseExterner Link", Chem. Commun. 2009, 7113-7115.

H.-D. Arndt, S. Schoof, J.-Y. Lu, "Thiopeptide antibiotic biosynthesisExterner Link", Angew. Chem. 2009, 121, 6900-6904; Angew. Chem. Int. Ed. 2009, 48, 6770-6773.

T. Walther, S. Renner, H. Waldmann, H.-D. Arndt, "Synthesis and structure-activity correlation of a brunsvicamide-inspired compound collectionExterner Link", ChemBioChem 2009, 10, 1153-1162.

P. Loos, M. Riedrich, H.-D. Arndt, "AzaExterner Link-Wittig access to chiral imidazol(in)esExterner Link", Chem. Commun. 2009, 1900-1902 ("Highlight" in: Synfacts 2009, 7, 728).

R. Tannert, T.-S. Hu, H.-D. Arndt, H. Waldmann, "Solid-phase based total synthesis of jasplakinolide by ring-closing metathesisExterner Link", Chem. Commun. 2009, 1493-1495.

B. Kilitoglu, H.-D. Arndt, "Scope of Tyrosine O-Arylations with Boronic Acids: Optimized Synthesis of an Orthogonally Protected IsodityrosineExterner Link", Synlett 2009, 720-723.

S. Schoof, S. Baumann, B. Ellinger, H.-D. Arndt, "A fluorescent probe for the 70S-ribosomal GTPase-associated centerExterner Link", ChemBioChem 2009, 10, 242-245.

 

2008

H. Waldmann, Y.-P. He, H. Tan, L. Arve, H.-D. Arndt, "Total synthesis of biphenomycin BExterner Link", Chem. Commun. 2008, 5562-5564. 

J.-Y. Lu, J. Keith, W.-Z. Shen, M. Schürmann, H. Preut, T. Jacob, H.-D. Arndt, "Regioselective Externer Linkde-novo synthesis of cyanohydroxy­pyridines with a concerted mechanismExterner Link", J. Am. Chem. Soc. 2008, 130, 13219-13221. 

N. Bisek, S. Wetzel, H.-D. Arndt, H. Waldmann, "Synthesis and conformational analysis of stevastelin C3 analogs and their activity against the dual-specific phosphatase VHRExterner Link", Chem. Eur. J. 2008, 14, 8847-8860.

H. Waldmann, T.-S. Hu, S. Renner, S. Menninger, R. Tannert, T. Oda, H.-D. Arndt, "Total synthesis of chondramide C and its binding mode to F-actinExterner Link", Angew. Chem. 2008, 120, 6573-6577; Angew. Chem. Int. Ed. 2008, 47, 6473-6477.

S. Baumann, S. Schoof, S. D. Harkal, H.-D. Arndt, "Mapping the binding site of thiopeptide antibiotics by proximity induced covalent capture (PICC)Externer Link", J. Am. Chem. Soc. 2008, 130, 5664-5666.

T. Walther, H.-D. Arndt, H. Waldmann, "Solid-support based total synthesis and stereochemical correction of brunsvicamide AExterner Link", Org. Lett. 2008, 10, 3199-3202. 

H.-D. Arndt, M. Riedrich, "Synthesis of marine alkaloids from the oroidin familyExterner Link", Angew. Chem. 2008, 120, 4864-4867; Angew. Chem. Int. Ed. 2008, 47, 4785-4788.

J.-Y. Lu, W.-Z. Shen, H. Preut, H.-D. Arndt, "(Externer LinkZ)-Methyl-2-(methoxyimino)-3-oxo-butyrateExterner Link", Acta. Cryst. E 2008, 64, o602.

 

2007

T.-S. Hu, R. Tannert, H.-D. Arndt, H. Waldmann, "Solid-phase based synthesis of jaspla­kinolide analogs by intramolecular azide/alkyne cycloadditionsExterner Link", Chem. Commun. 2007, 3942-3944.

R. Tannert, M. Schürmann, H. Preut, H.-D. Arndt, H. Waldmann, "(Externer LinkS)-3-((Externer LinkR)-2,4-dimethylpent-4-enoyl)-4-isopropyl-5,5-diphenyloxazolidin-2-oneExterner Link", Acta. Cryst. E 2007, 63, o4381.

H.-D. Arndt, S. Schoof, "Polyamide- and RNA-based activators in living cells: A major step towards controlling gene expressionExterner Link", ChemBioChem 2007, 8, 1095-1098.

J.-Y. Lu, H.-D. Arndt, "Hetero-Diels-Alder synthesis of 3-hydroxypyridines: Access to the nosiheptide coreExterner Link", J. Org. Chem. 2007, 72, 4205-4212.

M. Riedrich, S. D. Harkal, H.-D. Arndt, "Peptide-embedded heterocycles by mild single- and multiple Externer Linkaza-Wittig ring closuresExterner Link", Angew. Chem. 2007, 119, 2755-2758; Angew. Chem. Int. Ed. 2007, 46, 2701-2703.

R. L. Stafford, H.-D. Arndt, M. Brezinski, A. Ansari, P. B. Dervan, "Minimization of a DNA-protein dimerizerExterner Link", J. Am. Chem. Soc. 2007, 129, 2660-2668. 

R. Wesolowski, A. Sommer, H.-D. Arndt, U. Koert, P. Reiß, S. Wimmers, O. Strauss, "Functional studies on synthetic gramicidin-hybrid ion channels in cellsExterner Link", ChemBioChem 2007, 8, 513-520.

 

2006

H.-D. Arndt, "Small molecule modulators of transcriptionExterner Link", Angew. Chem. 2006, 118, 4664-4673; Angew. Chem. Int. Ed. 2006, 45, 4552-4560.

 

Before 2006

K. E. Hauschild, R. E. Metzler, H.-D. Arndt, R. Moretti, M. Raffaelle, P. B. Dervan, A. Z. Ansari, "Temperature-sensitive protein-DNA dimerizersExterner Link", Proc. Natl. Acad. Sci. USA 2005, 102, 5008-5013. 

Y. Kwon, H.-D. Arndt, Q. Mao, Y. Choi, Y. Kawazoe, P. B. Dervan, M. Uesugi, "A small molecule transcription factor mimicExterner Link", J. Am. Chem. Soc. 2004, 126, 15940-15941.

H.-D. Arndt, B. Ziemer, U. Koert, "On the folding propensity of cyclohexylether-Externer LinkδExterner Link-peptidesExterner Link", Org. Lett. 2004, 6, 3269-3271. 

H.-D. Arndt, R. Welz, S. Müller, B. Ziemer, U. Koert, "Stereoselective synthesis of Externer Linktrans-Externer Linkthreo-Externer Linktrans oligo-pyrrolidines: Potential RNA cleavage agentsExterner Link", Chem. Eur. J. 2004, 10, 3945-3962.

H.-D. Arndt, K. E. Hauschild, D. P. Sullivan, K. Lake, P. B. Dervan, A. Z. Ansari, "Toward artificial developmental regulatorsExterner Link", J. Am. Chem. Soc. 2003, 125, 13322-13323.

H.-D. Arndt, D. Bockelmann, A. Knoll, S. Lamberth, C. Griesinger, U. Koert, "Cation control in functional helical programming: NMR-structures of a d-l-peptide ion channelExterner Link", Angew. Chem. 2002, 114, 4234-4238; Angew. Chem. Int. Ed. 2002, 41, 4062-4065.

H.-D. Arndt, A. Vescovi, A. Schrey, J. R. Pfeifer, U. Koert, "Solution phase synthesis and purification of the minigramicidin ion channels and a succinyl-linked gramicidinExterner Link", Tetrahedron 2002, 58, 2789-2801. 

H.-D. Arndt, A. Knoll, U. Koert, "Cyclohexylether-Externer LinkδExterner Link-amino acids: New selec­tivity fil­ters in ion channelsExterner Link", Angew. Chem. 2001, 113, 2137-2140; Angew. Chem. Int. Ed. 2001, 40, 2076-2078.

H.-D. Arndt, A. Knoll, U. Koert, "Synthesis of minigramicidin ion channels and test of their hydrophobic match with the membraneExterner Link", ChemBioChem 2001, 2, 221-223.

H.-D. Arndt, K. Polborn, U. Koert, "Stereoselective synthesis of a terpyrrolidine unit, a poten­tial building block for anion recognitionExterner Link", Tetrahedron Lett. 1997, 38, 3879-3882.